500mg tablets of Depakote prolonged-launch Valproate or valproic acid is used primarily to take care of epilepsy and bipolar ailment and to stop migraine headaches.[21]
twelve.one Mechanism of Action Divalproex sodium dissociates on the valproate ion during the gastrointestinal tract. The mechanisms by which valproate exerts its therapeutic results haven't been proven.
Do not quit Depakote with out initial talking to a Health care service provider. Halting Depakote abruptly could cause critical difficulties. Stopping a seizure drugs out of the blue in the affected person who has epilepsy can result in seizures that will not cease (standing epilepticus).
Desk 3 lists remedy-emergent adverse reactions which have been noted by ≥ five% of Depakotetreated clients and for which the incidence was increased than from the placebo group, inside the placebo-controlled demo of adjunctive therapy for cure of intricate partial seizures.
The advantage of improved seizure Handle with better doses need to be weighed versus the opportunity of a larger incidence of adverse reactions.
If you encounter Unwanted side effects from your medications, focus on them with all your provider. Some side effects may perhaps move with time, but Other folks may well call for adjustments within the medication.
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1 Headache was the only real adverse response that occurred in ≥ 5% of patients in the substantial dose group and at an equivalent or greater incidence from the very low dose team.
Depakote is indicated as monotherapy and adjunctive therapy in the remedy of patients with sophisticated partial seizures that come about possibly in isolation or in Affiliation with other types of seizures.
Significant and deadly liver destruction has actually been linked to valproate, notably in the initial six months of remedy.
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Sometimes, liver harm may continue on Though the medicine is stopped. Your Health care provider will do blood tests to examine your liver prior to And through remedy with DEPAKOTE.
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Depakote tablets are meant for oral administration. Depakote tablets needs to be swallowed entire and should not be crushed or chewed. Individuals ought to be informed to get Depakote every single day as prescribed.